Drug Discovery Today: Disease Models
Available online 29 November 2014, doi:10.1016/j.ddmod.2014.10.002
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Computational models of blood diseases
A review of mathematical models for leukemia and lymphoma
Geoffrey ClappDoron Levy
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Recently, there has been significant activity in the mathematical community, aimed at developing quantitative tools for studying leukemia and lymphoma. Mathematical models have been applied to evaluate existing therapies and to suggest novel therapies. This article reviews the recent contributions of mathematical modeling to leukemia and lymphoma research. These developments suggest that mathematical modeling has great potential in this field. Collaboration between mathematicians, clinicians, and experimentalists can significantly improve leukemia and lymphoma therapy.